An overview of ebola its history and the ebola vaccine

Initial results were released in November ; all 20 volunteers developed antibodies against Ebola and there were no significant concerns raised about safety. The regimen consists of two vaccine components first vaccine as prime, followed by a second vaccine as boost [40] that are based on AdVac technology from Crucell Holland B. The Phase 2 trial enrolled adult volunteers and commenced in July in United Kingdom and France.

An overview of ebola its history and the ebola vaccine

The virus is transmitted to people from wild animals and spreads in the human population through human-to-human transmission. The — outbreak in West Africa involved major urban areas as well as rural ones. Community engagement is key to successfully controlling outbreaks.

Good outbreak control relies on applying a package of interventions, namely case management, infection prevention and control practices, surveillance and contact tracing, a good laboratory service, safe and dignified burials and social mobilisation. Early supportive care with rehydration, symptomatic treatment improves survival.

There is as yet no licensed treatment proven to neutralize the virus but a range of blood, immunological and drug therapies are under development. Background The Ebola virus causes an acute, serious illness which is often fatal if untreated.

The latter occurred in a village near the Ebola River, from which the disease takes its name. The — outbreak in West Africa was the largest and most complex Ebola outbreak since the virus was first discovered in There were more cases and deaths in this outbreak than all others combined.

It also spread between countries, starting in Guinea then moving across land borders to Sierra Leone and Liberia.


The virus family Filoviridae includes three genera: Cuevavirus, Marburgvirus, and Ebolavirus. Within the genus Ebolavirus, five species have been identified: The first three, Bundibugyo ebolavirus, Zaire ebolavirus, and Sudan ebolavirus have been associated with large outbreaks in Africa.

The virus causing the — West African outbreak belongs to the Zaire ebolavirus species.

An overview of ebola its history and the ebola vaccine

Transmission It is thought that fruit bats of the Pteropodidae family are natural Ebola virus hosts. Ebola is introduced into the human population through close contact with the blood, secretions, organs or other bodily fluids of infected animals such as chimpanzees, gorillas, fruit bats, monkeys, forest antelope and porcupines found ill or dead or in the rainforest.

WHO | Ebola virus disease: background and summary

Ebola then spreads through human-to-human transmission via direct contact through broken skin or mucous membranes with the blood, secretions, organs or other bodily fluids of infected people, and with surfaces and materials e. Health-care workers have frequently been infected while treating patients with suspected or confirmed EVD.

This has occurred through close contact with patients when infection control precautions are not strictly practiced. Burial ceremonies that involve direct contact with the body of the deceased can also contribute in the transmission of Ebola.

People remain infectious as long as their blood contains the virus. Sexual transmission More surveillance data and research are needed on the risks of sexual transmission, and particularly on the prevalence of viable and transmissible virus in semen over time.

In the interim, and based on present evidence, WHO recommends that: All Ebola survivors and their sexual partners should receive counselling to ensure safe sexual practices until their semen has twice tested negative.

Survivors should be provided with condoms. Male Ebola survivors should be offered semen testing at 3 months after onset of disease, and then, for those who test positive, every month thereafter until their semen tests negative for virus twice by RT-PCR, with an interval of one week between tests.

Ebola survivors and their sexual partners should either: Having tested negative, survivors can safely resume normal sexual practices without fear of Ebola virus transmission.Ebola Virus And The United States - The Ebola virus has come and gone through the United States, West Africa, and many other countries multiple times throughout history.

More than million people in the United States are infected with HIV 1 but government officials do not ban HIV infected children and adults from attending school, receiving medical care, being employed, or otherwise participating in society.

In fact, there are anti-discrimination laws that guarantee civil rights protections for Americans infected with HIV or living with AIDS. INGREDIENTS, EXCIPIENTS, ADDITIVES, ADJUVENTS Egg Protein.

Found in influenza and yellow fever vaccines, which are prepared using chicken eggs. Ordinarily, persons who are able to eat eggs or egg products safely can receive these vaccines. Ebola Virus Disease (EVD) is a rare and deadly disease in people and nonhuman primates.

The viruses that cause EVD are located mainly in sub-Saharan Africa. People can get EVD through direct contact with an infected animal (bat or nonhuman primate) or a sick or dead person infected with Ebola virus.

What are the signs and symptoms of Ebola Virus Disease? Overview, Control Strategies, and Lessons Learned in the CDC Response to the – Ebola Epidemic This report presents an overview of previous Ebola outbreaks and the – epidemic and observations about the epidemic’s implications for future public health responses.

et al. Implementing an Ebola vaccine study—Sierra.

Ebola virus disease - Wikipedia